Genetic Testing for Colorectal Cancer
Learn how genetic testing can identify your risk of inherited colorectal cancer, including Lynch syndrome and FAP.
What is Genetic Testing for Colorectal Cancer?
Genetic testing for colorectal cancer examines specific regions of your DNA to find inherited changes that could increase your chance of developing cancer in the colon or rectum. These tests can uncover hereditary syndromes that might not be obvious based on personal or family history alone.
Some inherited conditions, such as Lynch syndrome and familial adenomatous polyposis (FAP), are caused by mutations in genes that regulate cell growth and DNA repair. Identifying these changes can provide clarity around your personal cancer risk and inform care plans for family members who may share the same genetic background.
Why is Genetic Testing Important for Colorectal Cancer?
For individuals with a personal or family history of bowel cancer or related cancers, genetic testing offers a clearer picture of inherited risk. Knowing whether you carry a high-risk mutation allows you and your healthcare provider to take preventative steps, such as starting screening earlier or considering risk-reducing interventions.
If you’ve already been diagnosed with colorectal cancer, genetic results may influence your treatment plan and identify other cancers you or your relatives may be at risk of developing.
How our Genetic Testing for Colorectal Cancer Works
Our process starts with a detailed consultation to understand your medical and family history. If testing is recommended, you’ll be offered either a saliva or blood sample kit. Many patients prefer to complete the test at home using a secure postal saliva kit, which is returned to our partner laboratory using a pre-paid envelope.
Your DNA is then analysed for known mutations in genes such as MLH1, MSH2, MSH6, PMS2 and APC. Depending on your history, other genes may also be reviewed. Results are usually returned within 2 to 4 weeks, and your consultant will provide a personalised report that helps you interpret the findings.
If a mutation is found, we will guide you through the next steps, which may include further testing, enhanced screening or referrals for family members. We also liaise with genetic specialists to ensure your care remains thorough and coordinated.
Who Should Consider Genetic Testing for Colorectal Cancer?
You may benefit from testing if any of the following apply:
- You were diagnosed with colorectal cancer before the age of 50
- You have two or more close relatives with colorectal or related cancers
- A family member has been diagnosed with Lynch syndrome or FAP
- You have a personal or family history of multiple bowel polyps
- You are of Ashkenazi Jewish heritage, where certain gene mutations are more common
Our consultants will talk you through whether testing is appropriate, even if you’re unsure about your family history.
What’s the Difference Between Inherited and Sporadic Colorectal Cancer?
Sporadic colorectal cancer occurs due to random genetic changes over a lifetime and isn’t passed down through families. In contrast, inherited colorectal cancer results from gene mutations that are present from birth and can be passed on to children. These inherited forms tend to appear earlier in life and may increase the risk of other cancers. Identifying them early enables proactive, targeted care.
What are Lynch Syndrome and Familial Adenomatous Polyposis (FAP)?
Lynch syndrome, also known as hereditary non-polyposis colorectal cancer (HNPCC), is caused by mutations in genes that help repair damaged DNA. It raises the risk of several cancers, including colorectal, endometrial and ovarian cancers, often at a younger age than usual.
FAP is a separate inherited condition involving the APC gene. It leads to the formation of numerous colon polyps during adolescence or early adulthood. If untreated, these polyps almost always become cancerous. Early diagnosis through genetic testing is crucial for managing risk and planning appropriate interventions.
Genetic Testing for Colorectal Cancer FAQs
- Is genetic testing painful?
No. Testing involves a simple blood or saliva sample and is completely non-invasive.
- Can I do the test from home?
Yes, our service is fully home-based. We will send you a simple saliva collection kit, which you return to the laboratory in a prepaid envelope.
- How long does it take to get the results?
Results are typically available within 4–6 weeks. A detailed report will be sent to you directly.
- What can genetic testing tell me about my health?
It can identify genetic markers linked to certain inherited conditions, offering insights into your risk and helping guide treatment or preventive care.
- Who should consider genetic testing?
Anyone with a family history of genetic disorders or certain cancers, or those looking for personalised insights into long-term health, fertility, or wellness.
- If my test is positive, does it mean I will get cancer?
No. A positive result means you have a higher risk, but it does not guarantee that you will develop cancer. It provides valuable information to guide screening, prevention and treatment decisions.
- What if my results show a genetic mutation?
You’ll receive tailored support from our consultants, including next steps for monitoring or prevention. We can also help family members access testing if needed.
Why Choose The Forbury Clinic?
The Forbury Clinic provides private genetic testing with accuracy, efficiency and patient comfort in mind. Our expert clinicians use the latest diagnostic technology to ensure reliable results, helping you to understand your body and take control of your health. We prioritise a smooth experience with minimal waiting times, allowing for fast testing and efficient result processing.